Neurogenic Inflammation in Health and Disease, Volume 8Gabor Jancso Elsevier, 10/12/2008 - 368 páginas Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain.
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Índice
Part II Nerves Mediators and Receptors Involved in Neurogenic Inflammation | 37 |
Part III Modulation and Physiological Significance of Neurogenic Inflammation | 119 |
Part IV The Pathological Significance of Neurogenic Inflammation | 191 |
339 | |
Color Plates | 347 |
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Palavras e frases frequentes
acid action activation afferent nerves agonists airways anandamide anti-inflammatory antidromic arteries arthritis axon B2 receptor blood flow bradykinin-induced Brain Res C-fiber Ca2+ calcitonin gene-related peptide capsaicin capsaicin receptor cardiac CGRP contralateral cutaneous cytokines disease dorsal root ganglion dura mater effect of bradykinin endogenous experimental expression function galanin gastric gastrointestinal guinea pig heat histamine hyperalgesia immune immunoreactivity increase induced inflammatory response inhibition inhibitory innervation involved ion channel Jancsó G Levine JD Maggi mast cells mechanisms mediated mice migraine modulation myocardial nerve fibers neurogenic inflammation neurokinin neuropeptides Neurosci Neurosci Lett nitric oxide NK1 receptor nociceptive nociceptors ONOO pain pathway peptidergic peripheral perivascular Pharmacol Physiol plasma extravasation preconditioning primary sensory neurons proinflammatory prostaglandin receptor antagonist reflex release role sensitization sensory nerves sensory neuropeptides somatostatin studies substance sympathetic synovial synovium tachykinin NK1 tachykinin receptor tissues trigeminal TRPV1 TRPV1 receptor vagal afferents vanilloid receptor vascular vasodilatation vasodilator visceral vitro vivo